Wits Infectious Diseases and Oncology Research Institute

Wits Infectious Diseases and Oncology Research Institute, based in Johannesburg, South Africa, is a university research institute within the University of the Witwatersrand. Established in 2008, it focuses on translational and clinical research addressing major public health challenges in Africa. The institute integrates laboratory science, clinical trials, and population health to advance prevention, treatment, and policy in infectious diseases and related conditions.

Its publications highlight leadership in HIV prevention and vaccine development, including comparative immunogenicity analyses and evaluations of novel prime boost strategies. Research on PrEP safety in pregnancy, hybrid immunity in people living with HIV, and persistent viral infection underscores strengths in large multicentre trials and immunology. Contributions in leading medical journals reflect strong global collaborations and influence on clinical guidance.

A growing body of work addresses maternal health and climate change, examining heat exposure, health warning systems, and social determinants within holistic frameworks. Systematic reviews and policy oriented analyses demonstrate capacity to synthesize evidence and shape adaptation strategies. Together, these efforts position the institute as a key driver of innovation in infectious diseases, women health, and climate sensitive public health in Africa.