Aspro. Pascaline Fru

Pascaline Fru is a South African clinician-scientist whose work bridges surgical research, oncology, and precision medicine. Affiliated with leading academic hospitals in Johannesburg, including Charlotte Maxeke Johannesburg Academic Hospital and the University of the Witwatersrand, her scholarship integrates clinical insight with translational laboratory science to address pressing health challenges in the regional context.

Her research spans trauma surgery, cancer immunology, and hematologic malignancies. She has contributed to improving diagnostic and triage strategies in penetrating and geriatric trauma, while also advancing understanding of immune profiling and metabolic alterations in pancreatic cancer. These studies emphasize context-specific data to inform prognosis and therapeutic decision-making in African patient populations.

A central theme in her work is precision oncology, particularly drug repurposing and ex vivo drug sensitivity platforms for leukemia and multiple myeloma. By integrating high-throughput screening, metabolomics, and patient-derived models, she promotes personalized treatment strategies aimed at overcoming drug resistance and expanding therapeutic options within resource-constrained healthcare systems.