Dr. Denise Lawrie

Denise Lawrie is a South African clinical haematology researcher whose work centres on immunophenotyping, flow cytometry, and laboratory biomarkers in HIV-associated and haematological diseases. Affiliated with major academic hospitals and laboratories in Johannesburg and Cape Town, her research supports diagnostic innovation and context-specific reference standards within resource-limited settings.

Her publications highlight expertise in multicolour flow cytometry, validation of commercial immunophenotyping panels, and CD4 monitoring technologies. Significant contributions include establishing paediatric and adult lymphocyte reference intervals for South African populations and evaluating automated haematology parameters as biomarkers of infection and immune activation, particularly in people living with HIV.

Lawrie’s work on HIV-associated diffuse large B-cell lymphoma and bacteremia biomarkers advances understanding of immune dysregulation in high-burden settings. By integrating laboratory science with clinical application, her research strengthens diagnostic accuracy, informs transplantation and oncology care, and promotes locally relevant laboratory standards.