About
Penelope Moore is a South African immunologist internationally recognized for her leadership in HIV antibody research. Affiliated with major research institutes in South Africa, her work bridges basic immunology, clinical trials, and vaccine design, with a strong focus on broadly neutralizing antibodies and viral evolution in high-burden settings.
Her publications highlight deep expertise in HIV-1 envelope biology, neutralization escape, and resistance to CD4-binding site antibodies such as VRC01. She has advanced understanding of viral breakthrough in prevention trials, genetic diversity within the IGH locus, and immunogen features linked to breadth, informing next-generation vaccine strategies.
Recent studies extend to clinical development of monoclonal antibodies in adults and infants, alongside investigations of SARS-CoV-2 immunity in people living with HIV. By integrating population immunology, genomics, and translational trials, her work shapes prevention strategies and antibody-based interventions in Africa and globally.
AI Written based on the publications indexed for this author.
Metrics
19
Master’s students supervised
10
Doctoral students supervised