Dr. Zibusiso Mkandla

Zibusiso Mkandla is a biomedical researcher whose work centers on cardiometabolic disease, inflammation, and haemostatic dysfunction, with particular attention to diabetes and HIV-associated cardiovascular risk. Affiliated with institutions engaged in clinical and translational health research in Southern Africa, Mkandla integrates laboratory science with population-based studies to address pressing public health challenges.

The publication record highlights sustained investigation into platelet activation, platelet–leukocyte aggregates, and immune cell activation in type 2 diabetes and HIV infection. Through systematic reviews, meta-analyses, and experimental models, the research clarifies how antiretroviral therapy, impaired glucose tolerance, and chronic inflammation contribute to hypercoagulability and cardiovascular complications.

Additional contributions explore epigenetic regulation, cytokine dynamics, and the modulation of inflammatory pathways using pharmacological and nutraceutical interventions. Recent work on hypertension awareness further reflects an expanding interest in preventive cardiometabolic health. Collectively, these studies demonstrate expertise in translational immunometabolism and cardiovascular risk stratification.