Antiviral Gene Therapy Research Unit

Antiviral Gene Therapy Research Unit is a university-based research entity located in Johannesburg, South Africa, at the University of the Witwatersrand. Established in the late twentieth century, it operates within an academic medical research environment focused on translational biotechnology. The unit is dedicated to advancing molecular therapies for viral diseases, with particular emphasis on innovative nucleic acid–based interventions.

Its publications highlight a strong focus on hepatitis B virus and the pursuit of a functional cure through gene therapy. Core strengths include development of adeno-associated viral vectors, artificial microRNAs, designer nucleases, and in vitro transcribed RNA platforms. Research addresses durable viral suppression, cccDNA targeting, vector safety, and immunotoxicity, demonstrating deep expertise in both therapeutic design and delivery challenges.

The unit also contributes to next-generation vaccine strategies and genome editing policy, particularly within the African context. By bridging gene therapy and vaccine technologies, it advances clinically relevant solutions for infectious diseases while shaping discourse on equitable biotechnology development and regional capacity building.