Dr. Aurelie Deroubaix

Aurelie Deroubaix is a biomedical researcher specializing in molecular virology, cellular imaging, and host–pathogen interactions, with a strong focus on hepatitis B virus. Her work explores how viral proteins, particularly HBeAg and its precursors, modulate host signaling pathways and contribute to hepatocarcinogenesis. Through integrative cellular and molecular approaches, she investigates mechanisms underlying viral persistence and liver cancer development.

Her recent studies employ proteomics, mass spectrometry, and bioinformatic analyses to examine how HBV subgenotypes prevalent in sub-Saharan Africa dysregulate pathways such as MAPK and PI3K/Akt/mTOR. This research highlights genotype-specific oncogenic potential and identifies host factors linked to immune evasion, oxidative stress, and uncontrolled proliferation. Complementary in silico work further examines signaling inhibition in colorectal cancer models.

Deroubaix also demonstrates expertise in advanced microscopy, including confocal and Airyscan imaging, to resolve intracellular trafficking of viral proteins. Her broader contributions extend to SARS-CoV-2 imaging methodologies and experimental cell biology models, reflecting a multidisciplinary strength in combining imaging technologies with molecular virology to clarify mechanisms of infection and cancer progression.