Adj Sagren Naidoo

Sagren Naidoo is a South African nephrology researcher whose work centers on chronic kidney disease and its cardiovascular complications, with collaborations linked to major academic hospitals in Johannesburg. Research integrates clinical nephrology, cardiovascular imaging, and molecular genetics, with a strong focus on populations of African descent. Contributions address the intersection of inflammation, genetic susceptibility, and cardiometabolic risk in resource-constrained settings.

Publications highlight the role of endotoxemia, inflammatory cytokines, and gene polymorphisms—including TLR4, IL-6, TGF-β, and APOL1—in accelerating atherosclerosis among CKD patients. Studies connect molecular markers with carotid intima-media thickness and cardiac remodeling, advancing understanding of subclinical cardiovascular disease in African cohorts. Work on APOL1 variants and oxidized lipids provides insight into genetically mediated cardiovascular vulnerability.

Earlier research explored dialysis adequacy, volume overload, proteinuria in transplant recipients, and quality of life in peritoneal dialysis populations. By combining bioimpedance, echocardiography, and patient-reported outcomes, this body of work underscores a comprehensive approach to kidney care, spanning pathophysiology, clinical management, and socioeconomic determinants of health.