Paediatric Cardiology

Paediatric Cardiology at Chris Hani Baragwanath Academic Hospital in Johannesburg, South Africa, is a public tertiary academic unit affiliated with the University of the Witwatersrand. Established within one of the world largest hospitals, founded in 1941, the unit delivers specialized cardiac care to children across the region while serving as a key training center for pediatric cardiologists in sub-Saharan Africa.

Its research centers on pediatric heart failure, congenital and acquired heart disease, rheumatic heart disease, and cardiovascular complications of systemic illnesses such as sickle cell anemia and COVID-19. Clinical trials and translational studies evaluate novel therapies, including sacubitril valsartan and arginine supplementation, alongside echocardiographic and biomarker driven diagnostics to refine risk stratification and management.

The unit also advances genomic medicine and rare disease diagnosis, integrating clinical exome sequencing into resource constrained settings. Work on MIS-C, primary hyperoxaluria, and access to cardiac services highlights its commitment to context relevant innovation. Through rigorous clinical research and regional capacity building, the institution plays a leading role in strengthening pediatric cardiovascular care in Africa.